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Harmful and potentially harmful constituents (HPHC) are a subset of tobacco product constituents which may cause direct and indirect harm to product users. These compounds may be found in the tobacco product, tobacco smoke, or aerosol. (https://www.fda.gov/tobacco-products/rules-regulations-and-guidance/harmful-and-potentially-harmful-constituents-tobacco-products-and-tobacco-smoke-established-list).   

This example illustrated HPHC testing and smoking regimens for an ENDS product.