| Num | Domain | Example |
| 1 | Clinical Observations (CL) | Clinical signs for group-housed subjects may contain cage-level findings for which a particular subject cannot or has not been identified. For example, the technician may notice liquid stool in the cage but did not see which subject produced the stool. |
| 2 | Food and Water Consumption (FW) | Food consumption for group-housed subjects may be recorded at the cage level. This method for pooling allows grams/cage/day or grams/cage/week to be reported. |
| 3 | Laboratory Test Results (LB) | In small-animal studies there may be scheduled clinical chemistry tests where a single subject may not be able to provide the volume of blood needed for testing. Therefore, blood from multiple subjects may be drawn to get the appropriate volume. | 3 | Food and Water Consumption (FW) | Food consumption for group-housed subjects may be recorded at the cage level. This method for pooling allows grams/cage/day or grams/cage/week to be reported. |
| 4 | Pharmacokinetics Concentrations (PC) | In animal studies there may be scheduled blood draws at various time points, to be analyzed for the compound of interest. These concentrations are then used in pharmacokinetic or toxicokinetic calculations. A single subject may not be able to provide the volume of blood needed for testing and therefore blood from multiple subjects may be drawn to get the appropriate volume. |
| 5 | Pharmacokinetics Parameters (PP) | In most small animal studies it is not feasible to create a complete pharmacokinetic profile over time on an individual subject. Multiple subjects are sampled at any given time point and all contribute to a single pharmacokinetic profile. The POOLID reflects the pool of subjects that contributed to a pharmacokinetic profile. Note, however, that this does not indicate whether a subject contributed once or several times. In some instances, blood samples may have been pooled prior to analysis to achieve a certain volume, and POOLID will be reflected in the PC domain. When multiple pools in the PC domain contribute to a single pharmacokinetic profile, a new POOLID composed of all the subjects is used in PP. |