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This is an example showing the raw data table, trial design, and results from the in vitro bacterial reverse mutation test of an example study, Study #8325064. This bacterial reverse mutation test uses four different amino acid-requiring strains of Salmonella typhimurium (S. typhimurium) and one strain of Escherichia coli (E. coli) to detect point mutations, which involve substitution, addition or deletion of one or a few DNA base pairs. 

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In this example, the Trial Summary dataset, ts.xpt, includes many informational fields that may provide context at the study level, for Study 8325064.  Also, TSGRPID has been used to link records (name, location, country) related to the test facility (TSGRPID = 1) and records related to the Test Site (TSGRPID = 2). The Study Director is associated with the Test Facility and the Principal Investigator is associated with the Test Site. Finally, the Primary Treatment CAS Registry Number is not known and this is recorded as an empty TSVAL and UNKNOWN in the corresponding TSVALNF.

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Rowcaps Rows 1-2: Show two records for TSPARMCD = "GLPTYP", using TSSEQ to indicate multiple records, since both GLP Types apply for this example study.  Rows 9-12: Show that TSGRPID has been used to link records (name, location, country) related to the test facility (TSGRPID = 1). The Study Director is associated with the Test Facility. Rows 18-24: Show that this example study includes two different species of bacteria and a total of five strains.  Rows 18-22: Show that TSGRPID (TSGRPID = 2) has been used to link the information for one species (Salmonella) with four different strains that are tested in this example study. Rows 23-24: Show that TSGRPID (TSGRPID = 3) has been used to link the information for one species (Escherichia coli) with the strain that is tested in this example study. Dataset2 Row STUDYID ASSAYID DOMAIN TSSEQ TSGRPID TSPARMCD TSPARM TSVAL TSVALNF 1 8325064 Ames TS 1 GLPTYP Good Laboratory Practice Type FDA 2 8325064 Ames TS 2 GLPTYP Good Laboratory Practice Type OECD 3 8325064 Ames TS 1 STSTDTC Study Start Date 2015-07-29 4 8325064 Ames TS 1 STITLE Study Title The Bacterial Reverse Mutation Test, Study 8325064-1 5 8325064 Ames TS 1 SNDIGVER SEND Implementation Guide Version TOBACCO IMPLEMENTATION GUIDE VERSION 1.0 6 8325064 Ames TS 1 SNDCTVER SEND Controlled Terminology Version SEND Terminology 2021-09-30 7 8325064 Ames TS 1 SSPONSOR Sponsor Organization Example Sponsor Inc. 8 8325064 Ames TS 1 SPREFID Sponsor's Study Reference ID NOT APPLICABLE 9 8325064 Ames TS 1 1 TSTFNAM Test Facility Name Example Tox Lab Name 10 8325064 Ames TS 1 1 TSTFLOC Test Facility Location 10 Somewhere Street, Montgomery, AL 10000 11 8325064 Ames TS 1 1 TFCNTRY Test Facility Country USA 12 8325064 Ames TS 1 1 STDIR Study Director Dr. R. Smith 13 8325064 Ames TS 1 GLPFL GLP Flag N 14 8325064 Ames TS 1 ASTD Assay Standard OECD Test No. 471 15 8325064 Ames TS 1 ASTDV Assay Standard Version 2020-06-29 16 8325064 Ames TS 1 SSTYP Study Type GENOTOXICITY IN VITRO 17 8325064 Ames TS 1 SSSTYP Study Sub Type Bacterial Reverse Mutation Test 18 8325064 Ames TS 1 2 SPECIES Species Salmonella 19 8325064 Ames TS 1 2 STRAIN Strain TA98 20 8325064 Ames TS 1 2 STRAIN Strain TA100 21 8325064 Ames TS 1 2 STRAIN Strain TA1535 22 8325064 Ames TS 1 2 STRAIN Strain TA1537 23 8325064 Ames TS 1 3 SPECIES Species Escherichia coli 24 8325064 Ames TS 1 3 STRAIN Strain WP2 uvrA pKM101
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title Raw Data Table for Study 8325064
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This example trial set dataset, tx.xpt, shows information about the test conditions for SetA and SetR in this example study. For brevity, this does not show information for SetF, SetG, or any other sets.  A fully formed tx.xpt for this example study would include information about the test conditions for all sets. 

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