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Each domain dataset is distinguished by a unique, 2-character code that should be used consistently throughout the submission. This code, which is stored in the SDTM variable named DOMAIN, is used in 4 ways: as the dataset name, as the value of the DOMAIN variable in that dataset, as a prefix for most variable names in that dataset, and as a value in the RDOMAIN variable in relationship tables (see Section 8, Representing Relationships and Data).

Datasets and Domains - SENDIG v3.1.1 - Wiki (cdisc.org) 

When determining which general-observation class domain model is appropriate for reporting specific observations, refer to the domain definition included in the Assumptions section for each domain model (see Section 6, Domain Models Based on the General Observation Classes).

What or who is a subject

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