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Datasets and Domains - SENDIG v3.1.1 - Wiki (cdisc.org) 

Test results, examinations, and observations for subjects in a nonclinical study are represented in a series of SEND domains. A domain is defined as a collection of logically related observations with a common topic. The logic of the relationship may pertain to the scientific subject matter of the data or to its role in the study. 

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