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Datasets and Domains - SDTMIG v3.4 - Wiki (cdisc.org)

Observations about study subjects are normally collected for all subjects in a series of domains. A domain is defined as a

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collection of

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In most cases there is a one-to-one relationship between a conceptual domain and a dataset based on that domain, the words are used interchangeably in the standards and, therefore, by most users. The structures called “relationship datasets” were given that name because they are mechanisms for connecting information represented in different datasets rather than observations about study subjects. Note that none of the relationship datasets includes.

However, in a submission, these datasets need dataset names, and character strings used in those names are included in the CDISC Codelist called "SDTM Domain Abbreviations."

In conclusion, there is a clear distinction between the meaning of "domain" and "dataset" but given that the naming conventions are the same across both terms, in many cases they can be considered interchangeable.

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logically related observations with a common topic. The logic of the relationship may pertain to the scientific subject matter of the data or to its role in the trial. Each domain is represented by a single dataset.

Each domain dataset is distinguished by a unique, 2-character code that should be used consistently throughout the submission. This code, which is stored in the SDTM variable named DOMAIN, is used in 4 ways: as the dataset name, as the value of the DOMAIN variable in that dataset, as a prefix for most variable names in that dataset, and as a value in the RDOMAIN variable in relationship tables (see Section 8, Representing Relationships and Data).

All datasets are structured as flat files with rows representing observations and columns representing variables.

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Each

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dataset is

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described by metadata definitions that provide information about the variables used in the dataset. The metadata are described in a data definition document (i.e., a Define-XML document) that is submitted with the data to regulatory authorities. The Define-XML standard (available at https://www.cdisc.org

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/standards/data-exchange/define-xml) specifies metadata attributes to describe SDTM data.

Data represented in SDTM datasets include data as originally collected or received, data from the protocol, assigned data, and derived data. The SDTM lists only the name, label, and type, with a set of brief CDISC guidelines that provide a general description for each variable.