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All three datasets make use of the SPTOBID variable to identify the tobacco product under study, and the STRFID (Substance Reference Identifier) variable to represent the ingredient name. STRFID must be assigned by study sponsors to be unique with regard to the attributes that describe it. If, for instance, the same ingredient varies on one or more attribute (e.g., two different manufacturers supplied the same ingredient, each with different purities, that is used in two different components of the product), STRFID must be unique for each use to reflect this difference, even if they share the same common name, and/or the same IUPAC name and CAS number. (see note 5)See IT example which illustrates this below.

The IT example below shows 4 types of tobacco listed as tobacco ingredients (STRFID) for the Tobacco Product CIG01A (SPTOBID). The variable ITSPECIF shows the specification (variety) of the first three tobaccos. ITCAT is used to indicate that Reconstituted Tobacco is a complex ingredient. (it has two more components) ITCURMTH indicates the cure method. ITCPISP is used to indicate whether complex purchased ingredients were made to the applicant's specification. TMRF indicates the Tobacco Master Reference File. Note that there are two varieties of burley tobacco in this tobacco product, thus each is given a unique STRFID value (Burley Tobacco and Burley Tobacco 2).

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Finally, the IQ domain is used to represent the quantity (target, minimum and maximum) of each ingredient identified in STRFID that the product (SPTOBID) is designed to contain, with the units for these values represented in IQUNIT. The function of each ingredient is described in IQFUNCT. Ingredients that appear in more than one component of the tobacco product are quantified separately for each component. (see note 3) IQPARENT and IQLEVEL are used to identify the component/ingredient of which the ingredient in a record is a constituent component, and and at which level in the overall hierarchy the constituent ingredient appears. The following implementation rules apply:

• IQPARENT must correspond to a value of STRFID in the same dataset. If parent is null, the ingredient is considered a top-level component and is assigned a value of "1" in IQLEVEL.
• Records describing ingredients that are constituent ingredients of another ingredient/component listed in the dataset will have IQPARENT value equal to the STRFID of that ingredient/component. IQLEVEL will be set to n +1, where n=the parent record's value of IQLEVEL. 
• Every value of STRFID used in the IQ dataset that has an IQLEVEL >1 (See note 4) must >1 must have a matching value of STRFID in either:
  • The IT dataset (when IQCAT=TOBACCO INGREDIENT) or,
  • The IN dataset (when IQCAT=NON-TOBACCO INGREDIENT)
  • Therefore, IQCAT is required to relate ingredient quantity records in IQ to the associated ingredient attributes described in either IT or IN.

The use of IQLPARENT and IQLEVEL help make explicit the relationship between complex ingredients and their constituents, and can assist when totaling the quantities of an ingredient that appears in multiple components of a tobacco product. 
The concept map below illustrates the representation of the hierarchical relationships between a complex ingredient and its constituent ingredients in the IQ domain structure. 

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