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This is an example of a study where biomarker's of exposure biomarkers were collected. All subjects participated in a baseline biomarker assessment and smokers were then switched to exclusive use of their assigned product. Subjects were directed to use their assigned product exclusively for 6 months with collection of samples for biomarker assessment at Day 1 (Visit 1, baseline), Day 90 (Visit 2) and Day 180 (Visit 3). Blood and 24 hour urine samples were collected at each visit. 

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