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The FDA has established a list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke. Additionally, a list of 20 HPHCs from the full list of HPHCs, for which testing methods are well established and widely available. These HPHC list focuses on chemicals that are linked to the five most serious health effects of tobacco use (cancer, cardiovascular disease, respiratory effects, reproductive problems, and addiction.) 

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Biomarkers of Exposure -Example 1
Biomarkers of Exposure -Example 1