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In tobacco studies, biomarkers to assess exposure to tobacco products and biomarkers of potential harm are both of interest. Biomarkers of exposure are tobacco smote constituents or their metabolites in a biological fluid or tissue, hair or exhaled breath. They are not measurements of how these constituents interact with the body process/functions.  Biomarkers of  of harm or potential harm are measurements of an effect from exposure.  

Biomarkers of exposure are used to characterize exposure to constituents present in tobacco products (such as harmful and potentially harmful constituents (HPHCs) and to determine the potential health impact from use of these products. These biomarkers could be indicative of exposure to tobacco products or could be related to diet or environmental exposure. 

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