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Our Recommendations and Rationales:

For modeling Open-ended Findings Question vs. Prespecified Findings Question, analogy can be drawn from the MB domain modeling principles. For modeling pre-specified findings vs open-ended findings in MB, the approach has been:

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1. https://loinc.org/14722-3/ Presence
2. https://loinc.org/29953-7/ Titer

3. https://loinc.org/14611-8/ Pattern

   Example
   title IS Example 1
   Dataset wrap Name IS Dataset2 Row STUDYID DOMAIN USUBJID ISSEQ ISREFID ISGRPID ISTESTCD ISTEST ISBDAGNT ISTSTDTL ISTSTOPO ISORRES ISORRESU ISSTRESC ISSTRESN ISSTRESU ISSPEC ISMETHOD VISITNUM VISIT ISDTC 1 XYZ IS XYZ1234 1 19283746 1 ATAB Autoantibody NUCLEAR AUTOANTIGENS SCREEN POSITIVE POSITIVE SERUM FLUORESCENT IMMUNOASSAY 1 SCREENING 2018-06-20 2 XYZ IS XYZ1234 2 19283746 1a ATAB Autoantibody NUCLEAR AUTOANTIGENS QUANTIFY 1:340 340 340 titer SERUM FLUORESCENT IMMUNOASSAY 1 SCREENING 2018-06-20 3 XYZ IS XYZ1234 3 19283746 1a ATAB Autoantibody NUCLEAR AUTOANTIGENS STAINING PATTERN CYTOPLASMIC, SPECKLED PATTERN CYTOPLASMIC, SPECKLED PATTERN SERUM FLUORESCENT IMMUNOASSAY 1 SCREENING 2018-06-20 4 XYZ IS XYZ1234 4 19283746 1b ATAB Autoantibody NUCLEAR AUTOANTIGENS QUANTIFY 1:170 170 170 titer SERUM FLUORESCENT IMMUNOASSAY 1 SCREENING 2018-06-20 5 XYZ IS XYZ1234 5 19283746 1b ATAB Autoantibody NUCLEAR AUTOANTIGENS STAINING PATTERN NUCLEAR, NUCLEOLAR PATTERN NUCLEAR, NUCLEOLAR PATTERN SERUM FLUORESCENT IMMUNOASSAY 1 SCREENING 2018-06-20 6 XYZ IS XYZ1007 1 19283746 1 ATAB Autoantibody NUCLEAR AUTOANTIGENS SCREEN NEGATIVE NEGATIVE SERUM FLUORESCENT IMMUNOASSAY 1 SCREENING 2018-06-20

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