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The APACHE II, is a severity-of-disease classification system that uses a point score based upon on the initial values of 12 routine physiologic measurements, age, and previous health status to provide a general measure of severity of disease. It was modified from the original 30-item form to focus on items with the highest correlation to depressive symptoms in validation studies, and consists of 15 items, each with possible response options of "YES" or "NO". Note that the “YES” and “NO” responses for SDTM QS.QSORRES are recorded in QS.QSSTRESN based on the instrument's scoring manual, so that a QSSTRESN (and AVAL) value of 0 does not always represent a QSORRES response of "NO", and a QSSTRESN (and AVAL) value of 1 does not always represent a QSORRES response of "YES". As a result, transposition or reversal of question responses is not required. The total score is computed by adding the individual standardized item responses.

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. Scores range from 0 to 71 and higher scores correspond to more severe disease and a higher risk of death.

5     Key Data Checks

Each item has a possible value of 0 or 1. The computed total score consists of integer values ranging from 0 to 15.

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