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In this section, the inputs to these models and how they are represented in CDISC standards for submission to a regulatory authority are discussed. Model outputs are not currently covered in this section but may be covered in a later release. However, regulatory agencies expect full information to replicate the analysis based in the outputs.

Examples

Initial Population

• demographics (age, gender, and race)
• birth rate "if open system"
• morbidity/mortality 
• initial tobacco prevalence
• immigration rates "If open system"

Transition probabilities/rates for initial population

Transition into discussion of examples - to be discussed:

Selection of initial model input parameters is an important step during model development. Input parameters are typically chosen to represent characteristics of the entire population: transitional probabilities (initiation, cessation, quitting, switching) and health outcome (mortality and/or morbidity rates). The initial values of these parameters are typically estimated from sources representative of the population, such complex probability population survey and census. 

• initial population (file) - describing states of tobacco use covered by the model
• transition probability (file)

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