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In this section, the inputs to these models and how they are represented in CDISC standards for submission to a regulatory authority are discussed. “Model Model outputs are not currently covered in this section but may be covered in a later release. ” However, regulatory agencies expect full information to replicate the analysis based in the outputs.
Examples
Initial Population
- demographics (age, gender, and race)
- birth rate "if open system"
- morbidity/mortality
- initial tobacco prevalence
- immigration rates "If open system"
Transition probabilities/rates for initial population
Transition into discussion of examples - to be discussed:
Selection of initial model input parameters is an important step during model development. Input parameters are typically chosen to represent characteristics of the entire population: transitional probabilities (initiation, cessation, quitting, switching) and health outcome (mortality and/or morbidity rates). The initial values of these parameters are typically estimated from sources representative of the population, such complex probability population survey and census.
Examples
Initial Population
- demographics (age, gender, and race)
- birth rate "if open system"
- morbidity/mortality
- initial tobacco prevalence
- immigration rates "If open system"
Transition probabilities/rates for initial population
- initial population (file) - describing states of tobacco use covered by the model
- transition probability (file)
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