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The EDSS is an ordinal clinical rating scale that is used to measure the disability status of subjects. The item response is a range from 0 to 10 in half-point increments that measures the disability status. The Kurtzke Expanded Disability Status Scale (EDSS) and Kurtzke Functional Systems Scores (KFSS) instruments are intended to be used in conjunction with one another. The KFSS should first be administered by the evaluator and results from this assessment are then applied to determine an EDSS scale score (Kurtzke, 1983). A change in the EDSS should only occur if there has been a change of one or more in the Functional System (FS) scores
. Functional Systems (FS) are described in the reference article Appendix Ascores. Please review the published Kurtzke Functional Systems Scores (KFSS) for details on the functional system scores.Jira showSummary false server Issue Tracker (JIRA) serverId 85506ce4-3cb3-3d91-85ee-f633aaaf4a45 key QRSSUPP-479
The scale points include a numeric rating (0-10) and a definition of what is represented by the rating (e.g., 2.5 = "Minimal disability in two
FSJira showSummary false server Issue Tracker (JIRA) serverId 85506ce4-3cb3-3d91-85ee-f633aaaf4a45 key QRSSUPP-387
."). For the EDSS, RSORRES is populated with the text description while the numeric rating is represented in the standardized character and numeric result variables RSSTRESC and RSSTRESN.Jira showSummary false server Issue Tracker (JIRA) serverId 85506ce4-3cb3-3d91-85ee-f633aaaf4a45 key QRSSUPP-386 Three responses to the EDSS ratings exceeded the 200-character limit for the RSORRES variable and needed to be reduced to fewer than 200 characters. Section 4, SDTM Mapping Strategy, indicates which item responses were revised in order to fit the 200-character limit.
Terminology
RSCAT, RSTESTCD, and RSTEST values are included in CDISC Controlled Terminology.
A full list of value sets for the result fields is provided in Section 4, SDTM Mapping Strategy.
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| EDSS CRF Text over 200 characters | RSORRES Value | RSSTRESC | RSSTRESN |
| Normal neurological exam. | 0 | 0 | |
| No disability, minimal signs in one FS. | 1 | 1 | |
| No disability, minimal signs in more than one FS. | 1.5 | 1.5 | |
| Minimal disability in one FS. | 2 | 2 | |
| Minimal disability in two FS. | 2.5 | 2.5 | |
| Moderate disability in one FS or mild disability in three or four FS though fully ambulatory. | 3 | 3 | |
| Fully ambulatory but with moderate disability in one FS and one or two FS grade 2; or two FS grade 3 or five grade 2. | 3.5 | 3.5 | |
| Fully ambulatory without aid, self-sufficient, up and about some 12 hours a day despite relatively severe disability consisting of one FS grade 4, or combination of lesser grades exceeding limits of previous steps; able to walk without aid or rest some 500 meters. | Fully ambulatory without aid, self-sufficient, up and about some 12 hours a day despite relatively severe disability; able to walk without aid or rest some 500 meters. | 4 | 4 |
| Fully ambulatory without aid, up and about much of the day, able to work a full day, may otherwise have some limitation of full activity or require minimal assistance; characterized by relatively severe disability usually consisting of one FS grade 4 or combinations of lesser grades exceeding limits of previous steps; able to walk without aid or rest some 300 meters. | Fully ambulatory without aid, up much of the day, able to work a full day, may have some limitation of full activity or require minimal assistance; able to walk without aid or rest some 300 meters. | 4.5 | 4.5 |
| Ambulatory without aid or rest for about 200 meters; disability severe enough to impair full daily activities (e.g., to work a full day without special provisions). | 5 | 5 | |
| Ambulatory without aid for about 100 meters; disability severe enough to preclude full daily activities. | 5.5 | 5.5 | |
| Intermittent or unilateral constant assistance (cane, crutch, brace) required to walk about 100 meters with or without resting. | 6 | 6 | |
| Constant bilateral assistance (canes, crutches, braces) required to walk about 20 meters without resting. | 6.5 | 6.5 | |
| Unable to walk beyond approximately 5 meters even with aid, essentially restricted to wheelchair; wheels self in standard wheelchair and transfers alone; up and about in wheelchair some 12 hours a day. | Unable to walk beyond approximately 5 meters even with aid, essentially restricted to wheelchair; wheels self in standard wheelchair and transfers alone; up and about in wheelchair some 12 hrs a day. | 7 | 7 |
| Unable to take more than a few steps; restricted to wheelchair; may need aid in transfer; wheels self but cannot carry on in standard wheelchair a full day; May require motorized wheelchair. | 7.5 | 7.5 | |
| Essentially restricted to bed or chair or perambulated in wheelchair, but may be out of bed itself much of the day; retains many self-care functions; generally has effective use of arms. | 8 | 8 | |
| Essentially restricted to bed much of day; has some effective use of arm(s); retains some self-care functions. | 8.5 | 8.5 | |
| Helpless bed patient; can communicate and eat. | 9 | 9 | |
| Totally helpless bed patient; unable to communicate effectively or eat/swallow. | 9.5 | 9.5 | |
| Death due to MS. | 10 | 10 |
The EDSS Functional Systems (FS) are described in the reference article Appendix A as the following:
Pyramidal Functions
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Cerebellar Functions
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Brain Stem Functions
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Sensory Functions (revised 1982)
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Bowel and Bladder Functions (revised 1982)
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Visual (or Optic) Functions
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Cerebral (or Mental) Functions
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Other Functions
| 0. None. |
| 1. Any other neurologic findings attributed to MS (specify). |
| V. Unknown. |
End of Document
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