Richard's comments were that if you were to use the "MULTIPLE" convention in IS row 1 as appeared in the original example, ISBDAGNT= ANIMAL MIX ANTIGENS, MULTIPLE, then the suppIS dataset was created incorrectly. "MULTIPLE" requires QNAM to be xxx1-4. So if we want to keep the "MULTIPLE" in binding agent IS row 1, QNAM must be ISBDAG1-4.
However since the panel allergy results can also be reported by the region (as regional mixes), this ISBDAGNT= ANIMAL MIX ANTIGENS, MULTIPLE, doesn't make sense because this also implies multiple regions are associated with a single record, when in fact the IS row 1 record only indicates one region. So it is best to take the word "MULTIPLE" out of ISBDAGNT IS row 1.
Lastly, it seems odd to have dog, cat, horse, cow in QVAL because the panel antibody test targets dog dander, cat dander, horse dander, cow dander. QVAL values are imprecise and should be updated.
Dataset wrap |
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Rowcaps |
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Row 1: | Shows the detection of immunoglobulin E (IgE) antibody against multiple animal allergens. ISBDAGNT is used to house the generic but controlled value "ANIMAL MIX ANTIGENS". |
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Rows 2-3: | Show the amount of IgE antibody against dog dander and its RAST classification score. |
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Rows 4-5: | Show the amount of IgE antibody against cat dander and its RAST classification score. |
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Rows 6-7: | Show the amount of IgE antibody against horse dander and its RAST classification score. |
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Rows 8-9: | Show the amount of IgE antibody against cow dander and its RAST classification score. |
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Dataset2 |
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Row | STUDYID | DOMAIN | USUBJID | ISSEQ | ISGRPID | ISREFID | ISTESTCD | ISTEST | ISBDAGNT | ISTSTDTL | ISORRES | ISORRESU | ISSTRESC | ISSTRESN | ISSTRESU | ISSPEC | ISMETHOD | VISITNUM | VISIT | ISDTC |
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1 | XYZ | IS | XYZ1234 | 1 | 1 | 12453333 | ARIGEAB | Allergen-induced IgE Antibody | ANIMAL MIX ANTIGENS, MULTIPLE |
| POSITIVE |
| POSITIVE |
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| SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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2 | XYZ | IS | XYZ1234 | 2 | 2 | 12456666 | ARIGEAB | Allergen-induced IgE Antibody | DOG DANDER ANTIGEN |
| 0.12 | U/mL | 0.12 | 0.12 | U/mL | SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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3 | XYZ | IS | XYZ1234 | 3 | 2 | 12456666 | ARIGEAB | Allergen-induced IgE Antibody | DOG DANDER ANTIGEN | RAST SCORE | 0 |
| 0 | 0 |
| SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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4 | XYZ | IS | XYZ1234 | 4 | 3 | 12456666 | ARIGEAB | Allergen-induced IgE Antibody | CAT DANDER ANTIGEN |
| 0.19 | U/mL | 0.19 | 0.19 | U/mL | SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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5 | XYZ | IS | XYZ1234 | 5 | 3 | 12456666 | ARIGEAB | Allergen-induced IgE Antibody | CAT DANDER ANTIGEN | RAST SCORE | 0 |
| 0 | 0 |
| SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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6 | XYZ | IS | XYZ1234 | 6 | 4 | 12456666 | ARIGEAB | Allergen-induced IgE Antibody | COW DANDER ANTIGEN |
| 44 | U/mL | 44 | 44 | U/mL | SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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7 | XYZ | IS | XYZ1234 | 7 | 4 | 12456666 | ARIGEAB | Allergen-induced IgE Antibody | COW DANDER ANTIGEN | RAST SCORE | 4 |
| 4 | 4 |
| SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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8 | XYZ | IS | XYZ1234 | 8 | 5 | 12456666 | ARIGEAB | Allergen-induced IgE Antibody | HORSE DANDER ANTIGEN |
| 120 | U/mL | 120 | 120 | U/mL | SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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9 | XYZ | IS | XYZ1234 | 9 | 5 | 12456666 | ARIGEAB | Allergen-induced IgE Antibody | HORSE DANDER ANTIGEN | RAST SCORE | 6 |
| 6 | 6 |
| SERUM | RIA | 1 | SCREENING | 2018-06-20 |
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Dataset2 |
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Row | STUDYID | DOMAIN | USUBJID | IDVAR | IDVARVAL | QNAM | QLABEL | QVAL | QORIG | QEVAL |
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1 | XYZ | IS | XYZ1234 | ISSEQ | 1 | ISBDAG1 | Binding Agent 1 | DOG | CRF |
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2 | XYZ | IS | XYZ1234 | ISSEQ | 1 | ISBDAG2 | Binding Agent 2 | CAT | CRF |
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3 | XYZ | IS | XYZ1234 | ISSEQ | 1 | ISBDAG3 | Binding Agent 3 | HORSE | CRF |
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4 | XYZ | IS | XYZ1234 | ISSEQ | 1 | ISBDAG4 | Binding Agent 4 | COW | CRF |
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