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This example is currently in draft. |
This example shows findings from an assessment of the number of mutations within a tumor genome with the purpose of determining likely response to a therapeutic agent.
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| Row 1: | Shows the number of sequence variants variants within the region of interest. | | Row 2: | Shows the normalized number of sequence variants variants within the region of interest. The formula applied for normalization is shown in GFANMETH. The panel of genes used in next generation targeted sequencing is shown in SPDVID. | | Row 3: | Shows the a summary of the magnitude of the variant burden within the tumor. The panel of genes used in next generation targeted sequencing is shown in SPDVID. |
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| Dataset2 |
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| Row | STUDYID | DOMAIN | USUBJID | SPDEVID | GFSEQ | GFREFID | GFTESTCD | GFTEST | GFTSTDTL | GFORRES | GFORRESU | GFSTRESC | GFSTRESN | GFSTRESU | GFGENREF | GFNAM | GFSPEC | GFMETHOD | GFANMETH | VISITNUM | VISIT | VISITDY | GFDTC | GFDY | | 1 | ABC-123 | GF | ABC123-45-001 |
| 1 | 78975864 | TMB | Tumor Mutation Burden | NUMBER OF SEQUENCE VARIANTS | 497 |
| 497 | 497 |
| GRCh37.75 | Genetics Lab Plus | DNA | WHOLE EXOME SEQUENCING |
| 1 | SCREENING | <ADD HERE> | <ADD HERE> | <ADD HERE> | | 2 | ABC-123 | GF | ABC123-45-001 | ACME 500 GENE PANEL | 2 | 96757855 | TMB | Tumor Mutation Burden | NORMALIZED NUMBER OF SEQUENCE VARIANTS | 8.83 | /MBP | 8.83 | 8.83 | /MBP | GRCh37.75 | ACME Genetics Inc. | ctDNA | NEXT GENERATION TARGETED SEQUENCING | Uniform TMB Calculation Method Merino et al 2020 FORMULA | 1 | SCREENING | <ADD HERE> | <ADD HERE> | <ADD HERE> | | 3 | ABC-123 | GF | ABC123-45-001 | ACME 500 GENE PANEL | 3 | 96757855 | TMB | Tumor Mutation Burden | VARIANT SEQUENCE BURDEN INTERPRETATION | intermediate |
| intermediate |
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| GRCh37.75 | ACME Genetics Inc. | ctDNA | NEXT GENERATION TARGETED SEQUENCING |
| 1 | SCREENING | <ADD HERE> | <ADD HERE> | <ADD HERE> |
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