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This example is currently in draft. |
This example shows findings from an assessment of the number of mutations within a tumor genome with the purpose of determining likely response to immunotherapy. (Need to add description here)a therapeutic agent.
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| Row 1: | Shows the number of sequence variants variants within the region of interest. | | Row 2: | Shows the normalized number of sequence variants variants within the region of interest. The formula applied for normalization is shown in GFANMETH. | | Row 3: | Shows the a summary of the magnitude of the variant burden within the tumor. |
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| STUDYID | DOMAIN | USUBJID | SPDEVID | GFSEQ | GFREFID | GFTESTCD | GFTEST | GFTSTDTL | GFORRES | GFORRESU | GFSTRESC | GFSTRESN | GFSTRESU | GFGENREF | GFNAM | GFSPEC | GFMETHOD | GFANMETH | VISITNUM | VISIT | VISITDY | GFDTC | GFDY | | ABC-123 | GF | ABC123-45-001ACME 500 GENE PANEL |
| 1 | 9675785578975864 | TMB | Tumor Mutation Burden | NORMALIZED NUMBER OF SEQUENCE VARIANTS | 8.83 | /MBP | 8.83 | 8.83 | 497 |
| 497 | 497/MBP |
| GRCh37.75 | ACME Genetics Inc.Lab Plus | ctDNA | NEXT GENERATION TARGETED SEQUENCING | DNA | WHOLE EXOME SEQUENCINGUniform TMB Calculation Method Merino et al 2020 FORMULA |
| 1 | SCREENING | <ADD HERE> | <ADD HERE> | <ADD HERE> | | ABC-123 | GF | ABC123-45-001 | ACME 500 GENE PANEL | 2 | 96757855 | TMB | Tumor Mutation Burden | VARIANT SEQUENCE BURDEN INTERPRETATION | intermediate | NORMALIZED NUMBER OF SEQUENCE VARIANTS | 8.83 | /MBP | 8.83 | 8.83 | /MBPintermediate | GRCh37.75 | ACME Genetics Inc. | ctDNA | NEXT GENERATION TARGETED SEQUENCING | Uniform TMB Calculation Method Merino et al 2020 FORMULA | 1 | SCREENING | <ADD HERE> | <ADD HERE> | <ADD HERE> | | ABC-123 | GF | ABC123-45-001 | ACME 500 GENE PANEL | 3 | 7897586496757855 | TMB | Tumor Mutation Burden | NUMBER OF VARIANT SEQUENCE VARIANTSBURDEN INTERPRETATION | 497intermediate | 497 |
| 497intermediate |
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| GRCh37.75 | ACME Genetics Lab PlusInc. | DNA | ctDNA | NEXT GENERATION TARGETED WHOLE EXOME SEQUENCING |
| 1 | SCREENING | <ADD HERE> | <ADD HERE> | <ADD HERE> |
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