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There’s some difficulty in modeling this since there are basically two binding targets of the antibody – 1.) the antigen via the variable region of the antibody and 2.) The Fc receptor via the constant region of the antibody. A further subtlety is that constant regions of the antibodies can bind to multiple FcR’s, so it’s not like we can say we are measuring IgG1-antigen complex (ISTEST) binding to the FcR (ISBDAGNT). Modeled this would also mean we’d either blow ISTESTCD terminology or need a work-around such that antibody-antigen complexes could be listed in the SUPPIS.
The FC receptors, complement proteins, NK and phagocytes are all downstream effectors or cells that are recruited/activated by the FC region of the antibody, whether or not the effector is binding to the FC region is irrelevant. I think only complement 1B binds to the FC region, as well as the various Fc Receptors. The point is that they all are FC-medicated antibody effectors - perhaps this could be our new variable.
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