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There’s some difficulty in modeling this since there are basically two binding targets of the antibody – 1.) the antigen via the variable region of the antibody and 2.) The Fc receptor via the constant region of the antibody. A further subtlety is that constant regions of the antibodies can bind to multiple FcR’s, so it’s not like we can say we are measuring IgG1-antigen complex (ISTEST) binding to the FcR (ISBDAGNT). Modeled this would also mean we’d either blow ISTESTCD terminology or need a work-around such that antibody-antigen complexes could be listed in the SUPPIS.
If our end goal is to quantify the antibodies:
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Row | STUDYID | DOMAIN | USUBJID | SPDEVID | ISSEQ | ISGRPID | ISTESTCD | ISTEST | ISBDAGT | ISTSTDTL | ISORRES | ISORRESU | ISSTRESC | ISSTRESN | ISSTRESU | ISSPEC | ISMETHOD | ISDTC | 1 | ABC | IS | ABC-01-201 | ABC001 | 1 | 1 | GR3A158V | Fc Gamma Receptor IIIa Polymorphism 158V | IgG-Bound Influenza A H1 Hemagglutinin | 36920 | mdFI | 2013-08-26 | 2 | ABC | IS | ABC-01-201 | ABC001 | 2 | 1 | GR3A158F | Fc Gamma Receptor IIIa Polymorphism 158F | IgG-Bound Influenza A H1 Hemagglutinin | 31121 | mdFI | 2013-08-26 | |||||||||||||||||||||||||||||
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If our end goal is to quantify the Fc receptors:
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Questions:
- Is this a flow cytometry test? if so, should this be handled by CP? do you need to represent info such as "activated", gating?
- How many receptor polymorphisms are there?
- Before we agree to map this to IS, can we try to flash out the ISTESTs as much as possible for this type of assays?
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