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Lastly, i suppose you could represent aneurysms, arterial dissection, coronary occlusion all as clinical events and use the FACE structure, although i think they are findings about cardiovascular system so CV is a better place for them. However using FACE I have arrived to the same conclusion, see below. What's interesting about the concept map below is that it further shows how anatomical location values vary in --LOC depending on the SDTM class the data go into. As you summarized:
1. Anatomical focus of an intervention - at which part of the body an intervention is being made. (PR)
2. Anatomical manifestation of an event - the part of the body which shows a sign of the event occurring. (CE)
3. Anatomical object of an observation - about which part of the body is the observation being made. (FA/CV)
This shows me that a single --LOC variable for three classes, is an issue.
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