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We recently received this request: https://loinc.org/95971-8/ --- SARS CoV-2 stimulated gamma interferon [Presence] in Blood. We also recieved requests for the following LOINC codes: 95974-2, 95972-6, and 95973-4. Upon further research on all 4 LOINC codes, they are referring to the IFNg Response Assay, which has been modeled in the LB domain in the TB-TAUG.

The IFNG Response test toward M. Tuberculosis is modeled in the LB domain, in the TB-TAUG as the following:

...

  1. Where do you show that this challenge assay is done against the TB antigensM. Tuberculosis? - use NHOID?
  2. CP domain has developed a new standard variable called Test Condition Agent/CNDAGT, which is used to represent stimulating agents, like the values in ASSYAG above, should this variable be added to LB, or IS? CP Specification
  3. Lastly, Interferon-Gamma Response Assay is a classic immunological test, is it correct to map this to the LB domain?
    1. Can we model this in the IS domain, see example dataset below.
    2. If we model this test in IS, how do we distinguish it from the INFg test in lab. Can we draw the line where if we are running a routine lab test looking for IFNg level it goes to LB vs. IFNg response test toward a specific, known bug then it goes to IS?If this test remains in LB, should NHOID be added to LB in order to show the name of the bug? I remember this being discussed by Jon/Bess when they worked on the TB TAUG.


If we were to model this in IS:

Dataset wrap


Dataset2
hi1styleyellow
hi1column ISBDAGNT
tableidIS table 1


Row

STUDYID

DOMAIN

USUBJID

ISSEQ

ISGRPID

NHOID

ISTESTCD

ISTEST

ISCNDAGT

ISTSTDTL

ISORRES

ISORRESU

ISSTRESC

ISSTRESN

ISSTRESU

ISSPEC

ISMETHOD

VISITNUMVISIT

ISDTC

1

ABC

IS

ABC-01-201

1

1

Mycobacterium tuberculosis

IFNG

Interferon Gamma

Nil

1.3

IU/mL

1.3

1.3

IU/mL

PLASMABLOOD

ELISA




2

ABC

IS

ABC1230ABC-01-011201

2

1

Mycobacterium tuberculosisIFNG

Interferon Gamma

ESAT-6, CFP-10, TB 7.7


6.2

IU/mL

6.2

6.2

IU/mL

PLASMABLOOD

ELISA




3ABCIS

ABC1230ABC-01-011201

3

1

Mycobacterium tuberculosisIFNG

Interferon Gamma

Mitogen


0.9

IU/mL

0.9

0.9

IU/mL

PLASMABLOOD

ELISA




4ABCIS

ABC1230ABC-01-011201

4

1

Mycobacterium tuberculosisIFNG

Interferon Gamma


Interpretation

Positive


Positive



PLASMABLOOD

ELISA







Similarly if we were to model Jozef's request in IS for https://loinc.org/95971-8/ --- SARS CoV-2 stimulated gamma interferon [Presence] in Blood

Dataset wrap


Dataset2
hi1styleyellow
hi1column ISBDAGNT
tableidIS table 1


Row

STUDYID

DOMAIN

USUBJID

ISSEQ

ISGRPID

NHOID

ISTESTCD

ISTEST

ISCNDAGT

ISTSTDTL

ISORRES

ISORRESU

ISSTRESC

ISSTRESN

ISSTRESU

ISSPEC

ISMETHOD

VISITNUMVISIT

ISDTC

1

ABC

IS

ABCABC1230-01-201011

1

1

SARS-CoV-2

IFNG

Interferon Gamma

Nil

1.3

IU/mL

1.3

1.3

IU/mL

PLASMABLOOD

ELISA




2

ABC

IS

ABC1230-011

2

1

SARS-CoV-2IFNG

Interferon Gamma

SARS-CoV-2 Antigen

(SARS-CoV-2 Spike Protein, etc.)


6.2

IU/mL

6.2

6.2

IU/mL

PLASMABLOOD

ELISA




3ABCIS

ABC1230-011

3

1

SARS-CoV-2IFNG

Interferon Gamma

Mitogen


0.9

IU/mL

0.9

0.9

IU/mL

PLASMABLOOD

ELISA




4ABCIS

ABC1230-011

4

1

SARS-CoV-2IFNG

Interferon Gamma


Interpretation

PresentPositivePresent


Positive



PLASMABLOOD

ELISA